4-Chlorobenzenesulfonyl chloride → HCID 59679478, compound

To a stirring mixture of 3-oxa-9-aza-bicyclo[3.3.1]nonan-7-one (408 mg, 2.3 mmol) in dichloromethane (8 mL) was added Et3N (1.2 mL, 9.2 mmol) and 4-chlorobenzenesulfonyl chloride (582 mg, 2.76 mmol). The reaction mixture was stirred at room temperature for 2 h. The reaction mixture was diluted with dichloromethane (50 mL) and washed with a saturated aqueous NaHCO3 solution (15 mL). The aqueous phase was separated and extracted twice with EtOAc (2×25 mL). The combined organic phases were then dried (Na2SO4), filtered, concentrated under vacuum, and the residue was purified on a silica gel column (eluant hexane/EtOAc, 50/50 to 100) to give 510 mg (70%) of 9-(4-chloro-benzenesulfonyl)-3-oxa-9-aza-bicyclo[3.3.1]nonan-7-one as a white solid; Retention time (min)=1.687 min, Method [1], MS (ESI) 316.1 (M+H); 1H-NMR (300 MHz, CDCl3) δ 7.84-7.81 (m, 2H), 7.56-7.51 (m, 2H), 4.28-4.27 (m, 2H), 3.76 (d, J=12.1 Hz, 2H), 3.61 (d, J=11.5 Hz, 2H), 2.65 (dd, J=15.93, 5.49 Hz, 2H), 2.46 (d, J=15.93 Hz, 2H); 13C-NMR (75 MHz, CDCl3) δ 204.3, 140.1, 139.1, 130.1, 128.7, 71.7, 51.7, 44.4 ppm.

1. washwashed with a saturated aqueous NaHCO3 solution (15 mL)
2. customThe aqueous phase was separated
3. extractionextracted twice with EtOAc (2×25 mL)
4. dry with materialThe combined organic phases were then dried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated under vacuum
7. customthe residue was purified on a silica gel column (eluant hexane/EtOAc, 50/50 to 100)

ORD record

ord-020fd6dcde174110bbe7bd95e86baa73

Source dataset

uspto-grants-2010_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07754712B2