Sodium Carbonate → 2-Chloro-N-[2-(3-chloro-5-trifluoromethyl-pyrdin-2-yl)-ethyl]-6-methyl-nicotinamide

HRID 2354937Notes

Reaction equation

HRID 2354937 reaction equation
[ClH:1].[Cl:2][C:3]1[C:4]([CH2:13][CH2:14][NH2:15])=[N:5][CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[C:16](=[O:19])([O-])[O-].[Na+].[Na+]>C(#N)C>[Cl:1][C:6]1[N:5]=[C:4]([CH3:13])[CH:3]=[CH:8][C:7]=1[C:16]([NH:15][CH2:14][CH2:13][C:4]1[C:3]([Cl:2])=[CH:8][C:7]([C:9]([F:12])([F:10])[F:11])=[CH:6][N:5]=1)=[O:19]

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 669124442-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)ethan-1-amine hydrochloride

Product 1

HCID 99996832-Chloro-N-[2-(3-chloro-5-trifluoromethyl-pyrdin-2-yl)-ethyl]-6-methyl-nicotinamide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 161 mg (0.7 mmol) 2-chloro-6-methylnictotinyl chloride, 160 mg (0.7 mmol) 2-(3-chloro-5-trifluormethyl-pyridin-2-yl)-ethylamine hydrochloride and 236 mg (1.7 mmol) sodium carbonate in 8 ml acetonitrile is stirred for 3 days at room temperature.

Sources & evidence

ORD record
ord-7fb446f4c4b5436aa0aa2c441dfafdce
Source dataset
uspto-grants-2010_07
Patent number
US07754741B2

Reaction notes

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