HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 2-Chloro-N-[2-(3-chloro-5-trifluoromethyl-pyrdin-2-yl)-ethyl]-6-methyl-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)ethan-1-amine hydrochloride | HCID 66912444 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-Chloro-N-[2-(3-chloro-5-trifluoromethyl-pyrdin-2-yl)-ethyl]-6-methyl-nicotinamide | HCID 9999683 | — |
Reaction Steps
A solution of 161 mg (0.7 mmol) 2-chloro-6-methylnictotinyl chloride, 160 mg (0.7 mmol) 2-(3-chloro-5-trifluormethyl-pyridin-2-yl)-ethylamine hydrochloride and 236 mg (1.7 mmol) sodium carbonate in 8 ml acetonitrile is stirred for 3 days at room temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07754741B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-7fb446f4c4b5436aa0aa2c441dfafdce |
| Source note | uspto-grants-2010_07 |