2-Aminothiazole → HCID 10412229, compound

HRID 2354996Notes

Reaction equation

C[O:2][C:3](=O)[C:4]1[CH:9]=[C:8]([O:10][C@@H:11]([CH3:21])[CH2:12][O:13][Si](C(C)(C)C)(C)C)[CH:7]=[C:6]([O:22][C:23]2[CH:28]=[CH:27][C:26]([S:29]([CH3:32])(=[O:31])=[O:30])=[C:25]([F:33])[CH:24]=2)[CH:5]=1.[NH2:35][C:36]1[S:37][CH:38]=[CH:39][N:40]=1>>[F:33][C:25]1[CH:24]=[C:23]([CH:28]=[CH:27][C:26]=1[S:29]([CH3:32])(=[O:31])=[O:30])[O:22][C:6]1[CH:5]=[C:4]([CH:9]=[C:8]([O:10][CH:11]([CH3:21])[CH2:12][OH:13])[CH:7]=1)[C:3]([NH:35][C:36]1[S:37][CH:38]=[CH:39][N:40]=1)=[O:2]

Participants

Reactant 2

HCID 21552-Aminothiazole

HCID 68708666HCID 68708666, compound

Product 1

HCID 10412229HCID 10412229, compound

Procedure

The compound of Production Example 42 was obtained as a colorless oil using the obtained 5-((1S)-2-(t-butyldimethylsiloxy)-1-methyl-ethoxy)-3-(3-fluoro-4-methanesulfonyl-phenoxy)-benzoic acid methyl ester and 2-amino-thiazole, by the same method as in Production Example 2, a corresponding method, or a combination thereof with an ordinary method.

Workup

customThe compound of Production Example 42 was obtained as a colorless oil

Sources & evidence

ORD record: ord-15bbfc41cc0b44f29eced2a3d0cff71d
Source dataset: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07754743B2

Reaction notes

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