4-Chloropyridine hydrochloride → HCID 23093014, compound

HRID 2355042Notes

Reaction equation

HRID 2355042 reaction equation
CO[C:3](=[O:15])[C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6](OCOC)[CH:5]=1.Cl.Cl[C:18]1[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=1.[O:24]([CH2:32][C@H:33]([OH:35])[CH3:34])[Si](C(C)(C)C)(C)C.[NH2:36][C:37]1[CH:41]=[CH:40][N:39]([CH3:42])[N:38]=1>>[OH:24][CH2:32][CH:33]([CH3:34])[O:35][C:6]1[CH:7]=[C:8]([O:10][C:18]2[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=2)[CH:9]=[C:4]([CH:5]=1)[C:3]([NH:36][C:37]1[CH:41]=[CH:40][N:39]([CH3:42])[N:38]=1)=[O:15]

Participants

5

Reactant 4

HCID 818524-Chloropyridine hydrochlorideHCID 1372541-Methyl-3-aminopyrazoleHCID 13175135(2R)-1-{[(1,1-Dimethylethyl)(dimethyl)silyl]oxy}propan-2-olHCID 23136427Methyl 3-hydroxy-5-(methoxymethoxy)benzoate

Product 1

HCID 23093014HCID 23093014, compound

Procedure

The compound of Production Example 163 was obtained as a white amorphous substance using 5-hydroxy-3-methoxymethoxybenzoic acid methyl ester, 4-chloropyridine hydrochloride, (2R)-1-(t-butyldimethylsiloxy)-2-hydroxypropane and 3-amino-1-methyl-1H-pyrazole, by the same method as in Production Example 117, a corresponding method, or a combination thereof with an ordinary method.

Workup

  1. customThe compound of Production Example 163 was obtained as a white amorphous substance

Sources & evidence

ORD record
ord-53551d2250604aff940bdab031d40a36
Source dataset
uspto-grants-2010_07
Patent number
US07754743B2

Reaction notes

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