2-Amino-4-methylthiazole → HCID 59383112, compound

HRID 2355047Notes

Reaction equation

HRID 2355047 reaction equation
[C:1](=[NH:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N[C:16]1[S:17][CH:18]=[C:19]([CH3:21])[N:20]=1>C1(C)C=CC=CC=1>[C:1](=[N:14][C:16]1[S:17][CH:18]=[C:19]([CH3:21])[N:20]=1)([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 741432-Amino-4-methylthiazoleHCID 136809Benzophenone imine

Product 1

HCID 59383112HCID 59383112, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Benzophenone imine (39.8 g, 0.22 mol) is added to a solution of 2-Amino-4-methyl-1,3-thiazole (30 g, 0.261) in toluene (450 ml) and heated at reflux under an inert atmosphere for 18 h. The mixture is cooled to room temperature and washed with citrate buffer (2×250 ml), water (2×250 ml), brine (2×250 ml), dried (MgSO4 and decolourising charcoal), filtered and evaporated to an orange solid (42.9 g, 70%).

Workup

  1. temperatureheated
  2. temperatureat reflux under an inert atmosphere for 18 h
  3. washwashed with citrate buffer (2×250 ml), water (2×250 ml), brine (2×250 ml)
  4. dry with materialdried (MgSO4 and decolourising charcoal)
  5. filtrationfiltered
  6. customevaporated to an orange solid (42.9 g, 70%)

Sources & evidence

ORD record
ord-d1744385d419444ab950836ff5bea714
Source dataset
uspto-grants-2010_07
Patent number
US07754746B2

Reaction notes

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