2-Bromo-4-fluorophenol → HCID 68451978, compound

HRID 2355056Notes

Reaction equation

HRID 2355056 reaction equation
[ClH:1].FC(F)(F)C1C=CC=CC=1O[C@H]1CCNC1.[OH:18][C@@H:19]1[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20]1.[Br:31][C:32]1[CH:37]=[C:36]([F:38])[CH:35]=[CH:34][C:33]=1O>>[ClH:1].[Br:31][C:32]1[CH:37]=[C:36]([F:38])[CH:35]=[CH:34][C:33]=1[O:18][C@H:19]1[CH2:23][CH2:22][NH:21][CH2:20]1

Participants

4

Reactant 3

HCID 6054722-Bromo-4-fluorophenolHCID 6544479tert-Butyl (3R)-3-hydroxypyrrolidine-1-carboxylateHCID 46942099HCID 46942099, compound

Product 1

HCID 68451978HCID 68451978, compound

Procedure

The title compound was prepared in the same manner as described for (3S)-3-[2-(trifluoromethyl)phenoxy]pyrrolidine hydrochloride from tert-butyl (3R)-3-hydroxypyrrolidine-1-carboxylate and 2-bromo-4-fluorophenol. 1H NMR (300 MHz, DMSO-d6): δ 7.62 (m, 1H), 7.32 (m, 1H), 7.13 (m, 1H), 5.31 (s, 1H), 3.60 (m, 1H), 3.32 (m, 3H), 2.12 (m, 2H).

Sources & evidence

ORD record
ord-8bc96b7065bb498a942d68bdac92702c
Source dataset
uspto-grants-2010_07
Patent number
US07754745B2

Reaction notes

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