Water → HCID 23133595, compound

HRID 2355150Notes

Reaction equation

HRID 2355150 reaction equation
[C:1]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][C:4]([S:7][CH2:8][C:9](=[O:11])[CH3:10])=[CH:3][CH:2]=1.C(=O)(O)[O-:19].[Na+].OOS([O-])=O.[K+].[OH2:29]>CO>[C:1]1([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:6]=[CH:5][C:4]([S:7]([CH2:8][C:9](=[O:11])[CH3:10])(=[O:19])=[O:29])=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 962Water2×HCID 516892Sodium BicarbonateHCID 231335291-(1,1'-Biphenyl-4-ylthio)propan-2-oneHCID 23707502Potassium hydroxy sulfite

Product 1

HCID 23133595HCID 23133595, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-(1,1′-biphenyl-4-ylthio)propan-2-one (69 mg, 0.28 mmol) was stirred at room temperature with sodium bicarbonate (72 mg, 0.85 mmol), oxone ((525 mg, 0.85 mmol), water (5 ml) and methanol (10 ml) for 3 hours. Water (50 ml) was added and the product extracted into ethyl acetate (3×25 ml). The extracts were brine washed, sodium sulphate dried and evaporated to give 78 mg (99%) product that was of sufficient purity to use with out further purification.

Workup

  1. extractionthe product extracted into ethyl acetate (3×25 ml)
  2. washwashed
  3. dry with materialsodium sulphate dried
  4. customevaporated

Sources & evidence

ORD record
ord-0e628834fc2744c2a7c3e0c6bc7a2adc
Source dataset
uspto-grants-2010_07
Patent number
US07754750B2

Reaction notes

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