反应详情

温度

50 °C

Add sodium azide (2.44 g, 37.49 mmol) to crude 4-bromomethyl-2-chloro-benzoic acid methyl ester (7.6 g, 28.84 mmol) in anhydrous dimethylformamide (100 mL) at room temperature under argon gas. Stir the reaction mixture at 50° C. overnight. Quench the reaction mixture with water and extract with ether (3×). Combine the organic layers, wash with brine, dry over sodium sulfate, and concentrate to provide the crude product (5.8 g, 25.7 mmol).

1. customQuench the reaction mixture with water
2. extractionextract with ether (3×)
3. washCombine the organic layers, wash with brine
4. dry with materialdry over sodium sulfate
5. concentrationconcentrate