反应详情

Dissolve 3-[(tert-butoxycarbonyl-methyl-amino)-methyl]-benzoic acid methyl ester (1.70 g, 6.1 mmol) in tetrahydrofuran (60 mL) at 0° C. Add a 1M solution of lithium aluminum hydride in tetrahydrofuran (8 mL, 8 mmol) dropwise and stir for 2 hrs. Quench the reaction with water (3 mL), 5N sodium hydroxide solution (3 mL) and more water (9 mL), filter and concentrate. Purify the residue by chromatography (silica gel) eluting with 40-60% ethyl acetate/hexanes to provide the title compound (1.42 g, 93%).

1. customQuench
2. customthe reaction with water (3 mL), 5N sodium hydroxide solution (3 mL) and more water (9 mL)
3. filtrationfilter
4. concentrationconcentrate
5. customPurify the residue by chromatography (silica gel)
6. washeluting with 40-60% ethyl acetate/hexanes