Hydrochloric Acid → HCID 67177680, compound

Participants

Reaction Steps

Add 4M hydrogen chloride in 1,4-dioxane (25 mL) to a mixture of {4-[3-hydroxy-4-(3-methyl-butyryl)-2-trifluoromethyl-phenoxymethyl]-benzyl}-carbamic acid tert-butyl ester (1.4 g, 2.91 mmol) in anhydrous 1,4-dioxane (25 mL) and heat the reaction at 50° C. for 1.5 hrs. Cool the reaction mixture to room temperature, dilute with ethyl acetate, and filter to provide the product as a white solid (934 mg, 2.24 mmol, 77% yield).

Provenance & Evidence