Hydrochloric Acid → HCID 67177680, compound

HRID 2355292Notes

Reaction equation

HRID 2355292 reaction equation
[ClH:1].C(OC(=O)[NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([C:24](=[O:29])[CH2:25][CH:26]([CH3:28])[CH3:27])=[C:20]([OH:30])[C:19]=2[C:31]([F:34])([F:33])[F:32])=[CH:12][CH:11]=1)(C)(C)C>O1CCOCC1.C(OCC)(=O)C>[ClH:1].[NH2:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([C:24](=[O:29])[CH2:25][CH:26]([CH3:28])[CH3:27])=[C:20]([OH:30])[C:19]=2[C:31]([F:32])([F:33])[F:34])=[CH:14][CH:15]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59153161HCID 59153161, compound

Product 1

HCID 67177680HCID 67177680, compoundYield 77%

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent2×

Procedure

Add 4M hydrogen chloride in 1,4-dioxane (25 mL) to a mixture of {4-[3-hydroxy-4-(3-methyl-butyryl)-2-trifluoromethyl-phenoxymethyl]-benzyl}-carbamic acid tert-butyl ester (1.4 g, 2.91 mmol) in anhydrous 1,4-dioxane (25 mL) and heat the reaction at 50° C. for 1.5 hrs. Cool the reaction mixture to room temperature, dilute with ethyl acetate, and filter to provide the product as a white solid (934 mg, 2.24 mmol, 77% yield).

Workup

  1. temperatureheat
  2. customthe reaction at 50° C. for 1.5 hrs
  3. filtrationfilter

Sources & evidence

ORD record
ord-44cd2c9b2ddc46f08363cd8d18fd3c8c
Source dataset
uspto-grants-2010_07
Patent number
US07754742B2

Reaction notes

Loading…