HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2355294Generated: October 31, 2026
Hydrochloric Acid → [4-(Aminomethyl)phenyl]methanol--hydrogen chloride (1/1)
https://huagongshe.com/reaction/2355294
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl [4-(hydroxymethyl)benzyl]carbamate | HCID 2794813 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | [4-(Aminomethyl)phenyl]methanol--hydrogen chloride (1/1) | HCID 46738133 | — |
Reaction Steps
Add 4N hydrogen chloride in 1,4-dioxane (25 mL) to a solution of (4-hydroxymethyl-benzyl)-carbamic acid tert-butyl ester (3.0 g, 12.6 mmol) in 1,4-dioxane (25 mL). Heat the reaction mixture at 50° C. for 1 hr. Filter the solid and wash it with ethyl acetate to give the title compound (2.1 g, 12.1 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07754742B2 |
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| Source dataset | uspto-grants-2010_07 |
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| ORD ID | ord-878e544899e94d0f8188516809875dcf |
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| Source note | uspto-grants-2010_07 |
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