Hydrochloric Acid → [4-(Aminomethyl)phenyl]methanol--hydrogen chloride (1/1)

HRID 2355294Notes

Reaction equation

HRID 2355294 reaction equation
[ClH:1].C(OC(=O)[NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][OH:17])=[CH:12][CH:11]=1)(C)(C)C>O1CCOCC1>[ClH:1].[NH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][OH:17])=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 2794813tert-Butyl [4-(hydroxymethyl)benzyl]carbamate

Product 1

HCID 46738133[4-(Aminomethyl)phenyl]methanol--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Conditions

Temperature
50 °C

Procedure

Add 4N hydrogen chloride in 1,4-dioxane (25 mL) to a solution of (4-hydroxymethyl-benzyl)-carbamic acid tert-butyl ester (3.0 g, 12.6 mmol) in 1,4-dioxane (25 mL). Heat the reaction mixture at 50° C. for 1 hr. Filter the solid and wash it with ethyl acetate to give the title compound (2.1 g, 12.1 mmol).

Workup

  1. filtrationFilter the solid
  2. washwash it with ethyl acetate

Sources & evidence

ORD record
ord-878e544899e94d0f8188516809875dcf
Source dataset
uspto-grants-2010_07
Patent number
US07754742B2

Reaction notes

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