反应详情

温度

60 °C

Add a 2.5N solution of hydrogen chloride (10 mL, 25.00 mmol) to 1-trityl-1H-imidazole-4-carboxylic acid 4-[4-(3,3-dimethyl-butyryl)-3-hydroxy-2-trifluoromethyl-phenoxymethyl]-benzylamide (217 mg, 296 μmol) in ethanol (10 mL). Stir the reaction mixture for 1.5 hr at 60° C. Cool the reaction mixture to room temperature and filter the precipitate. To the filtrate add water to precipitate the product. Filter the precipitate and triturate it with ether to remove the remaining trityl impurity. Filter the solid to give the title compound as a white solid (121 mg, 83% yield). MS (m/z): 490 (M+1).

1. temperatureCool the reaction mixture to room temperature
2. filtrationfilter the precipitate
3. additionTo the filtrate add water
4. customto precipitate the product
5. filtrationFilter the precipitate
6. customtriturate it with ether
7. customto remove the remaining trityl impurity
8. filtrationFilter the solid