3,5-Diethoxy-4-fluoro-benzaldehyde → HCID 67400590, compound

HRID 2355604Notes

Reaction equation

HRID 2355604 reaction equation
C(OC1C=C(C=CC=1C)CN1CCC(NC2C=C(C=CN=2)C#N)CC1)C.Cl.Cl.[NH:29]1[CH2:34][CH2:33][CH:32]([NH:35][C:36]2[CH:37]=[C:38]([CH:41]=[CH:42][N:43]=2)[C:39]#[N:40])[CH2:31][CH2:30]1.[CH2:44]([O:46][C:47]1[CH:48]=[C:49]([CH:52]=[C:53]([O:56][CH2:57][CH3:58])[C:54]=1[F:55])[CH:50]=O)[CH3:45]>>[CH2:44]([O:46][C:47]1[CH:48]=[C:49]([CH:52]=[C:53]([O:56][CH2:57][CH3:58])[C:54]=1[F:55])[CH2:50][N:29]1[CH2:30][CH2:31][CH:32]([NH:35][C:36]2[CH:37]=[C:38]([CH:41]=[CH:42][N:43]=2)[C:39]#[N:40])[CH2:33][CH2:34]1)[CH3:45]

Participants

4

Reactant 3

HCID 591282733,5-Diethoxy-4-fluoro-benzaldehyde2×HCID 67398466HCID 67398466, compoundHCID 67401550HCID 67401550, compound

Product 1

HCID 67400590HCID 67400590, compound

Procedure

The title compound was prepared in analogy to the synthesis of 2-[1-(3-ethoxy-4-methyl-benzyl)-piperidin-4-ylamino]-isonicotinonitrile (example 189) from 2-(piperidin-4-ylamino)-isonicotinonitrile dihydrochloride (intermediate B15) and 3,5-diethoxy-4-fluoro-benzaldehyde (intermediate E5) in a yield of 4.3 mg (6%). MS (ISP): 399.3 [M+H]+.

Sources & evidence

ORD record
ord-ca6451186442413fb987efc51704ce04
Source dataset
uspto-grants-2010_07
Patent number
US07754744B2

Reaction notes

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