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HRID2355610

反应详情

EQUATION

反应方程式

HRID 2355610 的结构方程式

REACTANTS

反应物

3
结构：CCOc1cc(C=O)ccc1OC
HCID244728

3-Ethoxy-4-methoxybenzaldehyde

C10H12O3

结构：COC(=O)c1cnc(NC2CCNCC2)cc1C(F)(F)F.Cl.Cl
HCID42604213

未命名化合物

2 次

结构：CCOc1cc(CN2CCC(Nc3cc(C(F)(F)F)c(C(=O)O)cn3)CC2)ccc1O
HCID67401086

未命名化合物

PRODUCTS

生成物

1
结构：CCOc1cc(CN2CCC(Nc3cc(C(F)(F)F)c(C(=O)O)cn3)CC2)ccc1OC
HCID67398939

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in analogy to the synthesis of 6-[1-(3-ethoxy-4-hydroxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinic acid (example 201) from 6-(piperidin-4-ylamino)-4-trifluoromethyl-nicotinic acid methyl ester dihydrochloride (intermediate B7) and 3-ethoxy-4-methoxy-benzaldehyde (commercially available) in a yield of 15.3 mg (22%). MS (ISP): 454.2 [M+H]+.