HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Ethoxy-4-methoxybenzaldehyde → 6-[1-(3-Ethoxy-4-methoxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Ethoxy-4-methoxybenzaldehyde | HCID 244728 | — |
| Edukt | 6-(Piperidin-4-ylamino)-4-trifluoromethyl-nicotinic acid methyl ester dihydrochloride | HCID 42604213 | — |
| Edukt | 6-[1-(3-Ethoxy-4-hydroxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinic acid | HCID 67401086 | — |
| Produkt | 6-[1-(3-Ethoxy-4-methoxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinic acid | HCID 67398939 | — |
Reaktionsschritte
The title compound was prepared in analogy to the synthesis of 6-[1-(3-ethoxy-4-hydroxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinic acid (example 201) from 6-(piperidin-4-ylamino)-4-trifluoromethyl-nicotinic acid methyl ester dihydrochloride (intermediate B7) and 3-ethoxy-4-methoxy-benzaldehyde (commercially available) in a yield of 15.3 mg (22%). MS (ISP): 454.2 [M+H]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07754744B2 |
| Quelldatensatz | uspto-grants-2010_07 |
| ORD ID | ord-0ddf2ef552b2444c9329135c965360d1 |
| Quellennotiz | uspto-grants-2010_07 |