Diphosgene → HCID 86602837, compound

Participants

Reaction Steps

Trichloromethyl chloroformate (1.37 g) is added dropwise to a solution of methyl (2E)-4-(5-amino-2-chloro-4-fluorophenoxy)-3-methoxybut-2-enoate (2.0 g) in ethyl acetate (30 ml). The mixture is stirred overnight at room temperature. It is concentrated under vacuum and the residue obtained (2.3 g) is used as such in the subsequent reaction.

Provenance & Evidence