Diphosgene → HCID 86602837, compound

HRID 2355758Notes

Reaction equation

HRID 2355758 reaction equation
Cl[C:2](OC(Cl)(Cl)Cl)=[O:3].[NH2:9][C:10]1[C:11]([F:27])=[CH:12][C:13]([Cl:26])=[C:14]([CH:25]=1)[O:15][CH2:16]/[C:17](/[O:23][CH3:24])=[CH:18]\[C:19]([O:21][CH3:22])=[O:20]>C(OCC)(=O)C>[Cl:26][C:13]1[CH:12]=[C:11]([F:27])[C:10]([N:9]=[C:2]=[O:3])=[CH:25][C:14]=1[O:15][CH2:16]/[C:17](/[O:23][CH3:24])=[CH:18]\[C:19]([O:21][CH3:22])=[O:20]

Participants

4

Reactant 2

HCID 10426DiphosgeneHCID 21845332HCID 21845332, compound

Product 1

HCID 86602837HCID 86602837, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Trichloromethyl chloroformate (1.37 g) is added dropwise to a solution of methyl (2E)-4-(5-amino-2-chloro-4-fluorophenoxy)-3-methoxybut-2-enoate (2.0 g) in ethyl acetate (30 ml). The mixture is stirred overnight at room temperature. It is concentrated under vacuum and the residue obtained (2.3 g) is used as such in the subsequent reaction.

Workup

  1. concentrationIt is concentrated under vacuum
  2. customthe residue obtained (2.3 g)
  3. customsuch in the subsequent reaction

Sources & evidence

ORD record
ord-678234c437764324b93ba36bcd90637d
Source dataset
uspto-grants-2010_07
Patent number
US07754880B2

Reaction notes

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