HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4,4,4-trifluoroacetoacetate → HCID 86602838, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4,4,4-trifluoroacetoacetate | HCID 67793 | — |
| Reactant | HCID 24261921 | HCID 24261921 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 86602838 | HCID 86602838 | 109.4% |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
Ethyl trifluoroacetoacetate (2.54 g) is added to a solution of 2-(5-amino-2-chlorophenyl)-4,5-dimethyl-1,3-thiazole (2.20 g) in 110 ml of toluene; a catalytic amount of 4-dimethylaminopyridine is added, then the mixture is heated to 110° C. while distilling off the solvent. When reaction is complete, the residue is concentrated under vacuum; 3.80 g of product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07754880B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-e80eb81f079d427ca66b597f63831f50 |
| Source note | uspto-grants-2010_07 |