Ethyl 4,4,4-trifluoroacetoacetate → HCID 86602838, compound

HRID 2355760Notes

Reaction equation

HRID 2355760 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3](=[O:10])[CH2:4][C:5]([O:7]CC)=O.[NH2:13][C:14]1[CH:15]=[CH:16][C:17]([Cl:27])=[C:18]([C:20]2[S:21][C:22]([CH3:26])=[C:23]([CH3:25])[N:24]=2)[CH:19]=1>C1(C)C=CC=CC=1.CN(C)C1C=CN=CC=1>[Cl:27][C:17]1[CH:16]=[CH:15][C:14]([NH:13][C:5](=[O:7])[CH2:4][C:3](=[O:10])[C:2]([F:1])([F:11])[F:12])=[CH:19][C:18]=1[C:20]1[S:21][C:22]([CH3:26])=[C:23]([CH3:25])[N:24]=1

Participants

5

Reactant 2

HCID 67793Ethyl 4,4,4-trifluoroacetoacetateHCID 24261921HCID 24261921, compound

Product 1

HCID 86602838HCID 86602838, compoundYield 109.4%

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 1140TolueneSolvent

Conditions

Temperature
110 °C

Procedure

Ethyl trifluoroacetoacetate (2.54 g) is added to a solution of 2-(5-amino-2-chlorophenyl)-4,5-dimethyl-1,3-thiazole (2.20 g) in 110 ml of toluene; a catalytic amount of 4-dimethylaminopyridine is added, then the mixture is heated to 110° C. while distilling off the solvent. When reaction is complete, the residue is concentrated under vacuum; 3.80 g of product are obtained.

Workup

  1. distillationwhile distilling off the solvent
  2. customWhen reaction
  3. concentrationthe residue is concentrated under vacuum

Sources & evidence

ORD record
ord-e80eb81f079d427ca66b597f63831f50
Source dataset
uspto-grants-2010_07
Patent number
US07754880B2

Reaction notes

Loading…