反应详情

To a solution of N-benzylethylenediamine (6.0 g, 40 mmol) in toluene (50 ml) at 0° C. was added 1,1′-carbonylbis-1H-imidazole (7.8 g, 48 mmol). After stirring the mixture at room temperature overnight, the reaction mixture was washed with water, 5% aqueous citric acid solution and brine. The organic phase was dried over anhydrous magnesium sulfate, filtered and evaporated under reduced pressure. The residue was recrystallized with warm ethyl acetate and filtered off to give 1-benzylimidazolidin-2-one (3.47 g).

1. washthe reaction mixture was washed with water, 5% aqueous citric acid solution and brine
2. dry with materialThe organic phase was dried over anhydrous magnesium sulfate
3. filtrationfiltered
4. customevaporated under reduced pressure
5. customThe residue was recrystallized with warm ethyl acetate
6. filtrationfiltered off