Ammonia → HCID 86645636, compound

HRID 2355829Notes

Reaction equation

HRID 2355829 reaction equation
[CH3:1][N:2]([CH3:33])[C:3]1[CH:8]=[CH:7][C:6]([C:9](=O)[CH2:10][N:11]2[CH2:15][CH2:14][CH2:13][CH:12]2[C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH2:23][CH2:24][CH2:25][N:26]3[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]3)[CH:17]=2)=[CH:5][CH:4]=1.N>CO.C(Cl)Cl>[CH3:1][N:2]([CH3:33])[C:3]1[CH:8]=[CH:7][C:6]([C@H:9]2[C:21]3[C:16](=[CH:17][C:18]([O:22][CH2:23][CH2:24][CH2:25][N:26]4[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]4)=[CH:19][CH:20]=3)[C@@H:12]3[CH2:13][CH2:14][CH2:15][N:11]3[CH2:10]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 67543074HCID 67543074, compound

Product 1

HCID 86645636HCID 86645636, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

1-(4-Dimethylamino-phenyl)-2-{2-[3-(3-piperidin-1-yl-propoxy)-phenyl]-pyrrolidin-1-yl}-ethanone. Prepared as described in Example 8, Step 1, on a 2.70 mmol scale, to give 0.93 g (77%) of the desired product as a viscous oil after chromatography (NH3 in MeOH/CH2Cl2). MS: exact mass calcd for C28H39F3N3O2, 449.3; m/z found, 450.5 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-fda658fb01d1413f9d7450c81a0fafe1
Source dataset
uspto-grants-2010_07
Patent number
US07754882B2

Reaction notes

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