Ammonia → HCID 67543469, compound

HRID 2355830Notes

Reaction equation

HRID 2355830 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:12]=[C:13]([CH:17]3[CH2:21][CH2:20][CH2:19][N:18]3[CH2:22][C:23]([C:25]3[CH:26]=[C:27]([CH3:31])[CH:28]=[CH:29][CH:30]=3)=O)[CH:14]=[CH:15][CH:16]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.N>CO.C(Cl)Cl>[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:12]=[C:13]3[C:14]([C@H:23]([C:25]4[CH:26]=[C:27]([CH3:31])[CH:28]=[CH:29][CH:30]=4)[CH2:22][N:18]4[CH2:19][CH2:20][CH2:21][C@H:17]43)=[CH:15][CH:16]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 67543089HCID 67543089, compound

Product 1

HCID 67543469HCID 67543469, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

2-{2-[3-(3-Piperidin-1-yl-propoxy)-phenyl-pyrrolidin-1-yl}-1-m-tolyl-ethanone. Prepared as described in Example 8, Step 1, on a 2.70 mmol scale, to give 610 mg (54%) of the desired product as an orange oil after chromatography (NH3 in MeOH/CH2Cl2). MS: exact mass calcd for C27H36N2O2, 420.3; m/z found, 421.5 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8107135f4d5445ad8f57255c726b6b0c
Source dataset
uspto-grants-2010_07
Patent number
US07754882B2

Reaction notes

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