HCID 68452905, compound → HCID 68455470, compound

HRID 2356039Notes

Reaction equation

HRID 2356039 reaction equation
[CH3:1][N:2]([CH3:54])[C:3](=[O:53])[CH2:4][C@@H:5]([NH:14][C:15]1[CH:20]=[CH:19][C:18]([S:21]([NH:24][C:25]([C:27]2[CH:32]=[CH:31][C:30]([C:33]3[CH:38]=[CH:37][C:36]([CH2:39][CH2:40][C:41]([O:43]C(C)(C)C)=[O:42])=[CH:35][C:34]=3[O:48][CH3:49])=[CH:29][CH:28]=2)=[O:26])(=[O:23])=[O:22])=[CH:17][C:16]=1[N+:50]([O-:52])=[O:51])[CH2:6][S:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C(O)(C(F)(F)F)=O.ClCCl>[CH3:54][N:2]([CH3:1])[C:3](=[O:53])[CH2:4][C@@H:5]([NH:14][C:15]1[CH:20]=[CH:19][C:18]([S:21]([NH:24][C:25]([C:27]2[CH:32]=[CH:31][C:30]([C:33]3[CH:38]=[CH:37][C:36]([CH2:39][CH2:40][C:41]([OH:43])=[O:42])=[CH:35][C:34]=3[O:48][CH3:49])=[CH:29][CH:28]=2)=[O:26])(=[O:22])=[O:23])=[CH:17][C:16]=1[N+:50]([O-:52])=[O:51])[CH2:6][S:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 1

HCID 68452905HCID 68452905, compound

Product 1

HCID 68455470HCID 68455470, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture of Example 126B in TFA (20 mL) and dichloromethane (20 mL) at room temperature was stirred for 1 hour and concentrated to provide the desired product. MS (ESI (+)) m/e 721 (M+H)+.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-9589e2f1fec94767a0378731d1c23298
Source dataset
uspto-grants-2010_07
Patent number
US07754886B2

Reaction notes

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