Toluene → HCID 22730840, compound

HRID 2356070Notes

Reaction equation

HRID 2356070 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[CH:13][C:14]([CH2:21][CH2:22][C:23]([OH:25])=O)=[C:15]3[C:20]=2[N:19]=[CH:18][CH:17]=[CH:16]3)=[CH:7][CH:6]=1)=[O:4].C(Cl)(=O)C([Cl:29])=O.C1(C)C=CC=CC=1>ClCCl>[Cl:29][C:23](=[O:25])[CH2:22][CH2:21][C:14]1[CH:13]=[CH:12][C:11]([C:8]2[CH:9]=[CH:10][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][CH:7]=2)=[C:20]2[C:15]=1[CH:16]=[CH:17][CH:18]=[N:19]2

Participants

5

Reactant 3

HCID 1140TolueneHCID 65578Oxalyl chlorideHCID 22730792HCID 22730792, compound

Product 1

HCID 22730840HCID 22730840, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of Example 201H (1.65 g, 4.92 mmol) in dichloromethane (15 mL) at room temperature was treated oxalyl chloride (344 mg, 2.71 mmol), stirred for 20 minutes, treated with toluene (25 mL), and concentrated to provide the desired product.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-0692ed996aba49d4a01624b9e94cb34b
Source dataset
uspto-grants-2010_07
Patent number
US07754886B2

Reaction notes

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