Pyridine → HCID 22730448, compound

HRID 2356071Notes

Reaction equation

HRID 2356071 reaction equation
Cl[C:2](=[O:25])[CH2:3][CH2:4][C:5]1[CH:14]=[CH:13][C:12]([C:15]2[CH:24]=[CH:23][C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][CH:16]=2)=[C:11]2[C:6]=1[CH:7]=[CH:8][CH:9]=[N:10]2.[CH3:26][N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1.N1C=CC=CC=1>O1CCOCC1>[CH3:26][N:27]1[CH2:32][CH2:31][N:30]([C:2](=[O:25])[CH2:3][CH2:4][C:5]2[CH:14]=[CH:13][C:12]([C:15]3[CH:24]=[CH:23][C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][CH:16]=3)=[C:11]3[C:6]=2[CH:7]=[CH:8][CH:9]=[N:10]3)[CH2:29][CH2:28]1

Participants

5

Reactant 3

HCID 1049PyridineHCID 531671-MethylpiperazineHCID 22730840HCID 22730840, compound

Product 1

HCID 22730448HCID 22730448, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of Example 201I (300 mg, 0.85 mmol), 1-methylpiperazine (111 mg, 1.11 mmol), and pyridine (74 mg, 0.94 mmol) in dioxane (4 mL) at room temperature was stirred for 75 minutes and purified by flash column chromatography on silica gel with 90:10:0.5 dichloromethane/methanol/concentrated ammonium hydroxide to provide the desired product.

Workup

  1. custompurified by flash column chromatography on silica gel with 90:10:0.5 dichloromethane/methanol/concentrated ammonium hydroxide

Sources & evidence

ORD record
ord-547a2a5b9802485da82212c9bba2891a
Source dataset
uspto-grants-2010_07
Patent number
US07754886B2

Reaction notes

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