Potassium Hydroxide → HCID 178419146, compound

HRID 2356077Notes

Reaction equation

HRID 2356077 reaction equation
O1CCCO[B:2]1[C:7]1[CH:37]=[CH:36][C:10]([C:11]([NH:13][S:14]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][CH2:24][CH2:25][S:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[C:19]([N+:33]([O-:35])=[O:34])[CH:18]=2)(=[O:16])=[O:15])=[O:12])=[CH:9][CH:8]=1.[OH-].[K+]>C1COCC1>[BH2:2][C:7]1[CH:8]=[CH:9][C:10]([C:11]([NH:13][S:14]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][CH2:24][CH2:25][S:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[C:19]([N+:33]([O-:35])=[O:34])[CH:18]=2)(=[O:15])=[O:16])=[O:12])=[CH:36][CH:37]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 22730739HCID 22730739, compound

Product 1

HCID 178419146HCID 178419146, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of Example 214D (26.26 g, 48.5 mmol) in THF (250 mL) at room temperature was treated with 2M KOH (225 mL), stirred for 16 hours, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 70-100% ethyl acetate/hexanes to provide the desired product.

Workup

  1. concentrationconcentrated
  2. customThe concentrate was purified by flash column chromatography on silica gel with 70-100% ethyl acetate/hexanes

Sources & evidence

ORD record
ord-8caaf0fd89f746eaa4f3e0a8b26569ef
Source dataset
uspto-grants-2010_07
Patent number
US07754886B2

Reaction notes

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