Hydrochloric Acid → HCID 67863671, compound

HRID 235617Notes

Reaction equation

HRID 235617 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:17]2[C:22](=[O:23])[NH:21][C:20](=[O:24])[CH:19]=[N:18]2)[CH:5]=[C:6]([Cl:16])[C:7]=1[S:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=1.Cl>C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([N:17]2[C:22](=[O:23])[NH:21][C:20](=[O:24])[CH2:19][NH:18]2)[CH:5]=[C:6]([Cl:16])[C:7]=1[S:8][C:9]1[CH:10]=[CH:11][C:12]([CH3:15])=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86741257HCID 86741257, compound

Product 1

HCID 67863671HCID 67863671, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

20 g of 2-[3,5-dichloro-4-(4-methylthio-phenoxy)-phenyl]-1,2,4-triazine-3,5-(2H,4H)-dione were dissolved in 200 ml of hot glacial acetic acid. 25 g of tin(II) chloride·2H2O and then 100 ml of concentrated hydrochloric acid were added, and the mixture was subsequently heated for 4 hours under reflux. After cooling, the product was filtered off with suction, washed with water until neutral and recrystallized from 2-methoxyethanol; melting point 239° C.

Workup

  1. temperaturethe mixture was subsequently heated for 4 hours
  2. temperatureunder reflux
  3. temperatureAfter cooling
  4. filtrationthe product was filtered off with suction
  5. washwashed with water until neutral and
  6. customrecrystallized from 2-methoxyethanol

Sources & evidence

ORD record
ord-8b3322620f14462fb26766783e389bed
Source dataset
uspto-grants-1987_02
Patent number
US04640917

Reaction notes

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