Chloroform → HCID 13649829, compound

HRID 235625Notes

Reaction equation

HRID 235625 reaction equation
[Cl:1][C:2]1[NH:7][CH:6]([CH3:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-:17])=[O:16])[CH:10]=2)[C:3]=1[C:18]([O:20][CH2:21][CH3:22])=[O:19].C(N(CC)CC)C.C(Cl)(Cl)Cl.Cl[C:35]([O:37][CH3:38])=[O:36]>>[Cl:1][C:2]1[N:7]=[C:6]([CH3:8])[N:5]([C:35]([O:37][CH3:38])=[O:36])[CH:4]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-:17])=[O:16])[CH:10]=2)[C:3]=1[C:18]([O:20][CH2:21][CH3:22])=[O:19]

Participants

5

Reactant 4

HCID 6212ChloroformHCID 6586Methyl chloroformateHCID 8471TriethylamineHCID 20220122HCID 20220122, compound

Product 1

HCID 13649829HCID 13649829, compound

Procedure

To a solution of 6-chloro-5-ethoxycarbonyl-2-methyl-4-(3'-nitrophenyl)-dihydropyrimidine (0.5 g, 1.54 millimole) and triethylamine (1.6 g, 16 millimole) in 20 ml of chloroform 1.46 g (15.4 millimole) of methyl chloroformate was added dropwise with stirring in ice and the mixture was stirred at room temperature for 3 hours. The reaction solution was washed with 2% aqueous NaOH solution and then water, dried and evaporated to obtain 0.5 g of the title product as oil.

Workup

  1. stirringthe mixture was stirred at room temperature for 3 hours
  2. washThe reaction solution was washed with 2% aqueous NaOH solution
  3. dry with materialwater, dried
  4. customevaporated

Sources & evidence

ORD record
ord-8c8a5a2570544aaf9faaa19e26bf9cd9
Source dataset
uspto-grants-1987_02
Patent number
US04640922

Reaction notes

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