Trifluoroacetic acid → HCID 46318272, compound

HRID 2356276Notes

Reaction equation

HRID 2356276 reaction equation
C(OC([NH:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]([N:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:16])[CH2:11][CH2:10]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[N:17]1([C:15]([N:12]2[CH2:11][CH2:10][CH:9]([NH2:8])[CH2:14][CH2:13]2)=[O:16])[CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 46318296HCID 46318296, compound

Product 1

HCID 46318272HCID 46318272, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(tert-Butoxy)-N-[1-(pyrrolidinylcarbonyl)(4-piperidyl)]carboxamide (2.0 g, 6.73 mmol) was dissolved in 40 mL dichloromethane and trifluoroacetic acid (15 mL, 201.94 mmol) were added. The reaction mixture was stirred for 4 hours. The solvent was evaporated to give the product as a light brown semi-solid, which was used directly for the next step. (2.09 g, 6.73 mmol, 100%).

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-184311febbe24def9fc5e9903bad0aba
Source dataset
uspto-grants-2010_07
Patent number
US07759342B2

Reaction notes

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