反应详情

To a solution of LiAlH4 (1.1 g, 28.7 mmol) in THF (25 mL) at 0° C. was added dropwise via addition funnel a solution of hydroxy[1-(phenylmethyl)-4-piperidinyl]acetonitrile (2.2 g, 9.56 mmol) in THF (25 mL). After 12 h at 25° C., the solution was carefully quenched by dropwise additional of sodium potassium tartrate and extracted several times with DCM. The combined organic fractions were dried (Na2SO4) and concentrated yielding the title compound as a yellow oil which was used without further purification: LCMS (ES) m/e 235 (M+H)+.

1. customthe solution was carefully quenched by dropwise additional of sodium potassium tartrate
2. extractionextracted several times with DCM
3. dry with materialThe combined organic fractions were dried (Na2SO4)
4. concentrationconcentrated