反应详情

To a stirred solution of 4-(2-ethyl-6-fluoro-1-phenyl-1H-indol-3-yl)-piperidine-1-carboxylic acid tert-butyl ester (0.12 g) in DCM (20 ml) at r.t., is added trifluoroacetic acid (0.5 ml). After 15 h, the mixture is concentrated in vacuo. Flash chromatography (DCM:MeOH, gradient elution) of the resulting liquid gives 70 mg pure product (57%, TFA salt) as a beige solid after trituration with diethylether.

1. concentrationthe mixture is concentrated in vacuo
2. washFlash chromatography (DCM:MeOH, gradient elution) of the resulting liquid