Chloride → HCID 66850143, compound

HRID 2356471Notes

Reaction equation

HRID 2356471 reaction equation
[Cl-].[NH2:2][C:3]1[N:8]=[N:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:23]([F:26])([F:25])[F:24])=[O:16])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1>>[F:24][C:23]([F:26])([F:25])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[C:15]([N:12]1[CH2:11][CH2:10][N:9]([C:6]2[N:7]=[N:8][C:3]([NH:2][C:15](=[O:16])[CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[CH:4][CH:5]=2)[CH2:14][CH2:13]1)=[O:16]

Participants

3

Reactant 2

HCID 312ChlorideHCID 66849536[4-(6-Aminopyridazin-3-yl)piperazin-1-yl](2-trifluoromethylphenyl)methanone

Product 1

HCID 66850143HCID 66850143, compound

Procedure

Following the procedure of Example 6, making variations only as required to use hexyanoyl chloride in place of phenoxyacetyl chloride to react with [4-(6-aminopyridazin-3-yl)piperazin-1-yl](2-trifluoromethylphenyl)methanone, the title compound was obtained as a white solid (30% yield). 1H NMR (300 MHz, CDCl3) δ 11.65, 8.62, 7.75, 7.65, 7.58, 7.46-7.53, 7.37, 4.08, 3.88, 3.52-3.78, 3.30-3.40, 2.63, 1.72-1.79, 1.24-1.40, 0.90. MS (ES+) m/z 449.7 (M+1).

Sources & evidence

ORD record
ord-3fbd77d80798464ba87be6578b420d8f
Source dataset
uspto-grants-2010_07
Patent number
US07759348B2

Reaction notes

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