HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → (2-Benzyloxy-5-chloro-phenyl)-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Chlorosalicyl alcohol | HCID 79238 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | (2-Benzyloxy-5-chloro-phenyl)-methanol | HCID 19317759 | 106.4% |
Reaction Steps
4-Chloro-2-(hydroxymethyl)phenol (5 g, 31 mmol), benzyl bromide (3.74 ml, 31 mmol), and potassium carbonate (4.78 g, 34 mmol) were refluxed in acetone (30 ml) for two hours. TLC showed no more SM (starting material). Cooled down, filtered off the solid and vacuumed down (the filtrate) to give a clear oil (8.2 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07759369B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-3b780a849f664864b3792684e5fa354a |
| Source note | uspto-grants-2010_07 |