反应详情

4-Chloro-2-(hydroxymethyl)phenol (5 g, 31 mmol), benzyl bromide (3.74 ml, 31 mmol), and potassium carbonate (4.78 g, 34 mmol) were refluxed in acetone (30 ml) for two hours. TLC showed no more SM (starting material). Cooled down, filtered off the solid and vacuumed down (the filtrate) to give a clear oil (8.2 g).

1. temperatureCooled down
2. filtrationfiltered off the solid