Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2356608Generated: October 25, 2026

Thionyl Chloride → Ethyl 6-(chloromethyl)picolinate hydrochloride

https://huagongshe.com/reaction/2356608

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThionyl ChlorideHCID 24386—
Reactant2-Pyridinecarboxylic acid, 6-(hydroxymethyl)-, ethyl esterHCID 10921141—
SolventDichloromethaneHCID 6344—
ProductEthyl 6-(chloromethyl)picolinate hydrochlorideHCID 68457584—

Reaction Steps

As for Reaction 1, using 45.14 g of ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate and 33 g thionyl chloride in 500 ml dichloromethane. Yield 59.9 g

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07759369B2
Source datasetuspto-grants-2010_07
ORD IDord-183871bb9e68456ba638c22d39f17ad6
Source noteuspto-grants-2010_07