反应详情

Sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate (3.0 g) was suspended in ethyl acetate (100 ml) and water (100 ml) with stirring. Acetic acid (1.0 ml) was added to give two clear phases which were separated. The ethyl acetate layer was dried over magnesium sulfate and concentrated to give an oil which crystallised after a few minutes. Toluene (100 ml) was added and the solution was re-evaporated to give a white solid. Left at 20 mBar for 5 hours at 45° C. 2.69 g.

1. customto give two clear phases which
2. customwere separated
3. dry with materialThe ethyl acetate layer was dried over magnesium sulfate
4. concentrationconcentrated
5. customto give an oil which
6. customcrystallised after a few minutes
7. additionToluene (100 ml) was added
8. customthe solution was re-evaporated
9. customto give a white solid