4-{3-[2-(4-Fluorophenylamino)benzyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile → 4-[4,4-Dimethyl-2,5-dioxo-3-(2-phenylaminobenzyl)imidazolidin-1-yl]-2-trifluoromethylbenzonitrile

HRID 2356642Notes

Reaction equation

HRID 2356642 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:36]=[CH:35][CH:34]=[CH:33][C:10]=2[CH2:11][N:12]2[C:16]([CH3:18])([CH3:17])[C:15](=[O:19])[N:14]([C:20]3[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[C:22]([C:28]([F:31])([F:30])[F:29])[CH:21]=3)[C:13]2=[O:32])=[CH:4][CH:3]=1.C(C1C=CC(NC2C=CC=CC=2CN2C(C)(C)C(=O)N(C3C=CC(C#N)=C(C(F)(F)F)C=3)C2=O)=CC=1C(F)(F)F)#N>>[CH3:17][C:16]1([CH3:18])[C:15](=[O:19])[N:14]([C:20]2[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[C:22]([C:28]([F:31])([F:29])[F:30])[CH:21]=2)[C:13](=[O:32])[N:12]1[CH2:11][C:10]1[CH:33]=[CH:34][CH:35]=[CH:36][C:9]=1[NH:8][C:5]1[CH:6]=[CH:7][CH:2]=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 686792674-{3-[2-(4-Fluorophenylamino)benzyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrileHCID 867611454-{3-[2-(4-Cyano-3-trifluoromethylphenylamino)benzyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile

Product 1

HCID 578293104-[4,4-Dimethyl-2,5-dioxo-3-(2-phenylaminobenzyl)imidazolidin-1-yl]-2-trifluoromethylbenzonitrile

Procedure

The compounds of example 2, 4-{3-[2-(4-fluorophenylamino)benzyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile (molecular weight 496.15 (C26H20F4N4O2); retention time Rt=2.25 min. [B]; MS (ESI): 497.28 (MH+), and of examples 3, 4-{3-[2-(4-cyano-3-trifluoromethylphenylamino)benzyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile (molecular weight 571.14 (C28H19F6N5O2); retention time Rt=2.17 min. [B]; MS (ESI): 572.38 (MH+),

Sources & evidence

ORD record
ord-069f60383be945b48e3ee9e9ea6cea71
Source dataset
uspto-grants-2010_07
Patent number
US07759366B2

Reaction notes

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