4-{3-[2-(4-Fluorophenylamino)benzyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile → 4-[4,4-Dimethyl-2,5-dioxo-3-(2-phenylaminobenzyl)imidazolidin-1-yl]-2-trifluoromethylbenzonitrile

Participants

Role	Name	HCID	Charge
Reactant	4-{3-[2-(4-Fluorophenylamino)benzyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile	HCID 68679267	—
Reactant	4-{3-[2-(4-Cyano-3-trifluoromethylphenylamino)benzyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile	HCID 86761145	—
Product	4-[4,4-Dimethyl-2,5-dioxo-3-(2-phenylaminobenzyl)imidazolidin-1-yl]-2-trifluoromethylbenzonitrile	HCID 57829310	—

Reaction Steps

The compounds of example 2, 4-{3-[2-(4-fluorophenylamino)benzyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile (molecular weight 496.15 (C26H20F4N4O2); retention time Rt=2.25 min. [B]; MS (ESI): 497.28 (MH+), and of examples 3, 4-{3-[2-(4-cyano-3-trifluoromethylphenylamino)benzyl]-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl}-2-trifluoromethylbenzonitrile (molecular weight 571.14 (C28H19F6N5O2); retention time Rt=2.17 min. [B]; MS (ESI): 572.38 (MH+),

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07759366B2
Source dataset	uspto-grants-2010_07
ORD ID	ord-069f60383be945b48e3ee9e9ea6cea71
Source note	uspto-grants-2010_07