1-Bromo-2-(bromomethyl)-4-fluorobenzene → 4-[3-(2-Bromo-5-fluorobenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile

HRID 2356644Notes

Reaction equation

HRID 2356644 reaction equation
[CH3:1][C:2]1([CH3:21])[C:6](=[O:7])[N:5]([C:8]2[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[C:10]([C:16]([F:19])([F:18])[F:17])[CH:9]=2)[C:4](=[O:20])[NH:3]1.[Br:22][C:23]1[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:24]=1[CH2:25]Br>>[Br:22][C:23]1[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:24]=1[CH2:25][N:3]1[C:2]([CH3:21])([CH3:1])[C:6](=[O:7])[N:5]([C:8]2[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[C:10]([C:16]([F:19])([F:17])[F:18])[CH:9]=2)[C:4]1=[O:20]

Participants

3

Reactant 2

HCID 5179721-Bromo-2-(bromomethyl)-4-fluorobenzeneHCID 111622854-(4,4-Dimethyl-2,5-dioxoimidazolidin-1-yl)-2-trifluoromethylbenzonitrile

Product 1

HCID 686770214-[3-(2-Bromo-5-fluorobenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrileYield 95%

Procedure

Compound 15.2 was prepared as described for example 6.2 by reacting compound 1.1 with 2-bromo-5-fluorobenzyl bromide. 4-[3-(2-Bromo-5-fluorobenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile was obtained in a yield of 95% (molecular weight 483.02 (C20H14BrF4N3O2); retention time Rt=2.10 min. [B]; MS (ESI): 484.26 (MH+)

Sources & evidence

ORD record
ord-89b14e6ab60b406e91c0cf6ecf927587
Source dataset
uspto-grants-2010_07
Patent number
US07759366B2

Reaction notes

Loading…