1-Bromo-2-(bromomethyl)-4-fluorobenzene → 4-[3-(2-Bromo-5-fluorobenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile

Participants

Role	Name	HCID	Charge
Reactant	1-Bromo-2-(bromomethyl)-4-fluorobenzene	HCID 517972	—
Reactant	4-(4,4-Dimethyl-2,5-dioxoimidazolidin-1-yl)-2-trifluoromethylbenzonitrile	HCID 11162285	—
Product	4-[3-(2-Bromo-5-fluorobenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile	HCID 68677021	95%

Reaction Steps

Compound 15.2 was prepared as described for example 6.2 by reacting compound 1.1 with 2-bromo-5-fluorobenzyl bromide. 4-[3-(2-Bromo-5-fluorobenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile was obtained in a yield of 95% (molecular weight 483.02 (C20H14BrF4N3O2); retention time Rt=2.10 min. [B]; MS (ESI): 484.26 (MH+)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07759366B2
Source dataset	uspto-grants-2010_07
ORD ID	ord-89b14e6ab60b406e91c0cf6ecf927587
Source note	uspto-grants-2010_07