1-Bromo-2-(bromomethyl)-4-(trifluoromethyl)benzene → HCID 86633593, compound

HRID 2356646Notes

Reaction equation

HRID 2356646 reaction equation
[CH3:1][C:2]1([CH3:21])[C:6](=[O:7])[N:5]([C:8]2[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[C:10]([C:16]([F:19])([F:18])[F:17])[CH:9]=2)[C:4](=[O:20])[NH:3]1.[Br:22][C:23]1[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][C:24]=1[CH2:25]Br>>[Br:22][C:23]1[CH:30]=[CH:29][C:28]([C:31]([F:32])([F:33])[F:34])=[CH:27][C:24]=1[CH2:25][N:3]1[C:2]([CH3:21])([CH3:1])[C:6](=[O:7])[N:5]([C:8]2[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[C:10]([C:16]([F:19])([F:17])[F:18])[CH:9]=2)[C:4]1=[O:20]

Participants

3

Reactant 2

HCID 27562491-Bromo-2-(bromomethyl)-4-(trifluoromethyl)benzeneHCID 111622854-(4,4-Dimethyl-2,5-dioxoimidazolidin-1-yl)-2-trifluoromethylbenzonitrile

Product 1

HCID 86633593HCID 86633593, compoundYield 96%

Procedure

Compound 17.2 was prepared as described for example 6.2, by reacting compound 1.1 with 2-bromo-5-trifluoromethylbenzyl bromide. 4-[3-(2-Bromo-5-trifluoromethylbenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile was obtained in a yield of 96%. (Molecular weight 533.01 (C21H14BrF6N3O2); retention time Rt=2.21 min. [B]; MS (ESI): 534.14 (MH+)

Sources & evidence

ORD record
ord-ac618e41e3c34592933214d3bce5c9f1
Source dataset
uspto-grants-2010_07
Patent number
US07759366B2

Reaction notes

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