4-(5-Bromo-3-methyl-2-pyridinyl)butylamine → 3-[4-(5-Bromo-3-methylpyrid-2-yl)-butylamino]benzothiadiazine-1,1-dioxide

HRID 235667Notes

Reaction equation

HRID 235667 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH3:13])[C:5]([CH2:8][CH2:9][CH2:10][CH2:11][NH2:12])=[N:6][CH:7]=1.CS[N:16]1[CH2:21][C:20]2[CH:22]=[CH:23][CH:24]=[CH:25][C:19]=2[S:18](=[O:27])(=[O:26])[NH:17]1>>[Br:1][C:2]1[CH:3]=[C:4]([CH3:13])[C:5]([CH2:8][CH2:9][CH2:10][CH2:11][NH:12][N:16]2[CH2:21][C:20]3[CH:22]=[CH:23][CH:24]=[CH:25][C:19]=3[S:18](=[O:26])(=[O:27])[NH:17]2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 130942724-(5-Bromo-3-methyl-2-pyridinyl)butylamineHCID 198518743-Methylthiobenzothiadiazine-1,1-dioxide

Product 1

HCID 198518673-[4-(5-Bromo-3-methylpyrid-2-yl)-butylamino]benzothiadiazine-1,1-dioxide

Procedure

4-(5-Bromo-3-methylpyrid-2-yl)-butylamine (0.73 g) and 3-methylthiobenzothiadiazine-1,1-dioxide (0.68 g) were fused at 130°-140° C. for 3 hours. The product was crystallised from acetonitrile to yield 3-[4-(5-bromo-3-methylpyrid-2-yl)-butylamino]benzothiadiazine-1,1-dioxide m.p. 187°-8° C.

Workup

  1. customThe product was crystallised from acetonitrile

Sources & evidence

ORD record
ord-46d501a6a5134b25aada1ec5c953e339
Source dataset
uspto-grants-1987_02
Patent number
US04640926

Reaction notes

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