Phosgene → HCID 57829296, compound

HRID 2356685Notes

Reaction equation

HRID 2356685 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:5]([C:14]#[N:15])=[CH:4][CH:3]=1.Cl.[NH2:17][C:18]([CH3:27])([CH3:26])[C:19](OC(C)(C)C)=[O:20].[C:28](Cl)(Cl)=[O:29]>>[CH3:27][C:18]1([CH3:26])[C:19](=[O:20])[N:1]([C:2]2[CH:7]=[C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[C:5]([C:14]#[N:15])=[CH:4][CH:3]=2)[C:28](=[O:29])[NH:17]1

Participants

4

Reactant 3

HCID 6371PhosgeneHCID 12186776Tert-butyl 2-amino-2-methylpropanoate hydrochlorideHCID 441582825-Aminobiphenyl-2-carbonitrile

Product 1

HCID 57829296HCID 57829296, compound

Procedure

Compound 223.1 was prepared by the process as described for 1.1 by reaction of 223.3 with tert-butyl 2-amino-2-methylpropionate hydrochloride and phosgene (solution in toluene). 1H NMR: 8.73, s, 1H; 8.09, d, 1H, 7.75, s, 1H, 7.69, d, 1H, 7.62-7.5, m, 5H, 1.42, s, 6H.

Sources & evidence

ORD record
ord-dbab09d5006d4350bff37c3cf64214ad
Source dataset
uspto-grants-2010_07
Patent number
US07759366B2

Reaction notes

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