HRID2356689

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)N1Cc1ccccc1Br

HCID58154346

未命名化合物

HCID68676932

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C(Cc1ccc(Nc2ccccc2CN2C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1)C(=O)OC

HCID57829315

未命名化合物

PROCEDURE

实验过程

232 was obtained by reacting compound 232.2 with compound 1.2 under conditions as described for the preparation of compound I. Molecular weight 622.20 (C32H29F3N4O6); retention time Rt=2.21 min. [B]; MS (ESI): 623.21 (MH+).

WORKUP

后处理

custom232 was obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c22dcc885fde4548b2c846084aec091c
来源数据集: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07759366B2
来源说明: uspto-grants-2010_07

反应 SMILES

Cl.[NH2:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][CH:8]([C:13]([O:15][CH3:16])=[O:14])[C:9]([O:11][CH3:12])=[O:10])=[CH:5][CH:4]=1.Br[C:20]1[CH:47]=[CH:46][CH:45]=[CH:44][C:21]=1[CH2:22][N:23]1[C:27]([CH3:29])([CH3:28])[C:26](=[O:30])[N:25]([C:31]2[CH:38]=[CH:37][C:34]([C:35]#[N:36])=[C:33]([C:39]([F:42])([F:41])[F:40])[CH:32]=2)[C:24]1=[O:43]>>[C:35]([C:34]1[CH:37]=[CH:38][C:31]([N:25]2[C:26](=[O:30])[C:27]([CH3:29])([CH3:28])[N:23]([CH2:22][C:21]3[CH:44]=[CH:45][CH:46]=[CH:47][C:20]=3[NH:2][C:3]3[CH:4]=[CH:5][C:6]([CH2:7][CH:8]([C:9]([O:11][CH3:12])=[O:10])[C:13]([O:15][CH3:16])=[O:14])=[CH:17][CH:18]=3)[C:24]2=[O:43])=[CH:32][C:33]=1[C:39]([F:40])([F:42])[F:41])#[N:36]