4-[3-(2-Bromobenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile → Dimethyl 2-(4-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenylamino}benzyl)malonate

HRID 2356689Notes

Reaction equation

HRID 2356689 reaction equation
Cl.[NH2:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][CH:8]([C:13]([O:15][CH3:16])=[O:14])[C:9]([O:11][CH3:12])=[O:10])=[CH:5][CH:4]=1.Br[C:20]1[CH:47]=[CH:46][CH:45]=[CH:44][C:21]=1[CH2:22][N:23]1[C:27]([CH3:29])([CH3:28])[C:26](=[O:30])[N:25]([C:31]2[CH:38]=[CH:37][C:34]([C:35]#[N:36])=[C:33]([C:39]([F:42])([F:41])[F:40])[CH:32]=2)[C:24]1=[O:43]>>[C:35]([C:34]1[CH:37]=[CH:38][C:31]([N:25]2[C:26](=[O:30])[C:27]([CH3:29])([CH3:28])[N:23]([CH2:22][C:21]3[CH:44]=[CH:45][CH:46]=[CH:47][C:20]=3[NH:2][C:3]3[CH:4]=[CH:5][C:6]([CH2:7][CH:8]([C:9]([O:11][CH3:12])=[O:10])[C:13]([O:15][CH3:16])=[O:14])=[CH:17][CH:18]=3)[C:24]2=[O:43])=[CH:32][C:33]=1[C:39]([F:40])([F:42])[F:41])#[N:36]

Participants

3

Reactant 2

HCID 581543464-[3-(2-Bromobenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrileHCID 68676932HCID 68676932, compound

Product 1

HCID 57829315Dimethyl 2-(4-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenylamino}benzyl)malonate

Procedure

232 was obtained by reacting compound 232.2 with compound 1.2 under conditions as described for the preparation of compound I. Molecular weight 622.20 (C32H29F3N4O6); retention time Rt=2.21 min. [B]; MS (ESI): 623.21 (MH+).

Workup

  1. custom232 was obtained

Sources & evidence

ORD record
ord-c22dcc885fde4548b2c846084aec091c
Source dataset
uspto-grants-2010_07
Patent number
US07759366B2

Reaction notes

Loading…