Ethyl formate → HCID 178522621, compound

HRID 2356705Notes

Reaction equation

HRID 2356705 reaction equation
[NH2:1][C:2]1[NH:6][C:5]([C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)=[N:4][C:3]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[CH:20](OCC)=[O:21]>>[CH:20]([NH:1][C:2]1[NH:6][C:5]([C:7]2[CH:8]=[CH:9][C:10]([F:13])=[CH:11][CH:12]=2)=[N:4][C:3]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:21]

Participants

3

Reactant 2

HCID 8025Ethyl formateHCID 178509086HCID 178509086, compound

Product 1

HCID 178522621HCID 178522621, compound

Procedure

A mixture of 5-amino-2-(4-fluorophenyl)-4-phenylimidazole (1.00 g) and ethyl formate (10 ml) was refluxed for 15 hours. After cooling, the reaction mixture was concentrated under reduced pressure and crystallized from diethyl ether to obtain 5-formylamino-2-(4-fluorophenyl)-4-phenylimidazole (1.17 g) as colorless crystal.

Workup

  1. temperaturewas refluxed for 15 hours
  2. temperatureAfter cooling
  3. concentrationthe reaction mixture was concentrated under reduced pressure
  4. customcrystallized from diethyl ether

Sources & evidence

ORD record
ord-87734763126a41739e7236ed01c9a4aa
Source dataset
uspto-grants-2010_07
Patent number
US07759373B2

Reaction notes

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