Ethyl formate → HCID 178520836, compound

HRID 2356710Notes

Reaction equation

HRID 2356710 reaction equation
[CH2:1]([NH:3][C:4]1[NH:8][C:7]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[N:6][C:5]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH3:2].[CH:22](OCC)=[O:23]>>[CH:22]([CH2:2][CH2:1][NH:3][C:4]1[NH:8][C:7]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[N:6][C:5]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:23]

Participants

3

Reactant 2

HCID 8025Ethyl formateHCID 178463641HCID 178463641, compound

Product 1

HCID 178520836HCID 178520836, compound

Procedure

A mixture of 5-ethylamino-2-(4-fluorophenyl)-4-phenyl-imidazole (145 mg) in ethyl formate (8 ml) was refluxed for 8 hours. After cooling, the mixture was concentrated under reduced pressure, and crystallized from diethyl ether to obtain 5-formylethylamino-2-(4-fluorophenyl)-4-phenylimidazole (136 mg) as colorless crystal.

Workup

  1. temperaturewas refluxed for 8 hours
  2. temperatureAfter cooling
  3. concentrationthe mixture was concentrated under reduced pressure
  4. customcrystallized from diethyl ether

Sources & evidence

ORD record
ord-a404832884a04690832ce65e15b68d95
Source dataset
uspto-grants-2010_07
Patent number
US07759373B2

Reaction notes

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