Dichloromethane → HCID 67547600, compound

HRID 2356712Notes

Reaction equation

HRID 2356712 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]2[N:8](C)[C:9](O)=[C:10]([C:12]3[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=3)[N:11]=2)=[CH:4][CH:3]=1.S(Cl)([Cl:22])=O.[CH2:24](Cl)[Cl:25]>>[ClH:1].[ClH:22].[Cl:1][C:2]1[S:6][C:5]([C:7]2[NH:8][C:9]([CH2:24][Cl:25])=[C:10]([C:12]3[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=3)[N:11]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 24386Thionyl ChlorideHCID 67547577HCID 67547577, compound

Product 1

HCID 67547600HCID 67547600, compound

Procedure

To a solution of 2-(5-chlorothiophen-2-yl)-5-hydroxy-methyl-4-(3-pyridyl) imidazole (200 mg) in methylene chloride (5 ml) was added thionyl chloride (5 ml), and the mixture was refluxed for one hour. After cooling, the reaction mixture was concentrated under reduced pressure to obtain a crude product of 2-(5-chlorothiophen-2-yl)-5-chloromethyl-4-(3-pyridyl)-imidazole dihydrochloride (260 mg) as yellowish powder.

Workup

  1. temperaturethe mixture was refluxed for one hour
  2. temperatureAfter cooling
  3. concentrationthe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-621517c19f2a4edf94473524de86c170
Source dataset
uspto-grants-2010_07
Patent number
US07759373B2

Reaction notes

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